VitalFactors
The label, verified: what is in it, as printed on the box, and why the formula is built this way.
The full label
Serving size 2 Tablets · 20 servings per container
| Ingredient | Per serving | % DV |
|---|---|---|
| Calories | 24 | |
| Total Carbohydrates | 0.48 g | <1%† |
| Sodium | 274 mg | 12% |
| Vitamin A (as Retinyl Palmitate) | 30 mcg RAE | 2% |
| Vitamin C (as L-Ascorbic Acid) | 100 mg | 111% |
| Vitamin D3 (as Cholecalciferol) | 12.5 mcg (500 IU) | 63% |
| Vitamin E (as D-Alpha-Tocopherol Acetate) | 10 mg | 67% |
| Vitamin B1 (from Thiamin Hydrochloride) | 3 mg | 250% |
| Vitamin B2 (as Riboflavin) | 3.4 mg | 262% |
| Niacinamide | 24 mg | 150% |
| Vitamin B6 (from Pyridoxine) | 6 mg | 353% |
| Folic Acid (from Pteroyl-L-Monoglutamic Acid) | 200 mcg DFE | 50% |
| Vitamin B12 (from Methylcobalamin) | 200 mcg | 8333% |
| Biotin | 50 mcg | 167% |
| Pantothenic Acid | 2 mg | 40% |
| Calcium (from Calcium Carbonate) | 50 mg | 4% |
| Magnesium (from Trimagnesium Dicitrate) | 60 mg | 14% |
| Selenium (from Selenomethionine) | 20 mcg | 40% |
| Potassium | 330 mg | 7% |
| Proprietary Blend | 3.524 g (3524 mg) | |
| L-Glutamine | * | |
| NMN (ß-Nicotinamide Mononucleotide) | * | |
| Arginine (as L-Arginine Hydrochloride) | * | |
| Lysine (as L-Lysine Hydrochloride) | * | |
| Glycine | * | |
| Monk Fruit Extract (Momordica Grosvenovi, Fruit) | * | |
| Grape Skin Extract (40% Resveratrol) | * | |
| Coenzyme Q10 | * | |
| Grape Seed Extract (Vitis Vinifera)(95% Proanthocyanidins) | * | |
| Soy Isoflavones (contains Soy) | * | |
| Green Tea Extract (EGCG - Epigallocatechin Gallate) | * | |
| Laminaria Japonica Seaweed (80% Polysaccharides) | * | |
| Resveratrol (from resVida®**) | * | |
| Lycopene | * | |
| Superoxide Dismutase/Catalase (from Extramel®*** Melon) | * | |
| Ornithine (as L-Ornithine Hydrochloride) | * | |
| Lotus Seed Extract (Nelumbo Nucifera ****) | * | |
| NADH (Nicotinamide Adenine Dinucleotide Hydrogen) | * |
Other ingredients: Citric Acid, Sodium Bicarbonate, Potassium Bicarbonate, Red Fruit Jelly Flavor, Berry Flavor, Steviol Glycosides.
- † Percent Daily Values are based on a 2,000 calorie diet
- * Daily Value not established.
- ** Resvida® is a U.S. & international registered trademark of DSM (Netherlands).
- *** Extramel® is a U.S. registered trademark of Bionov Corp.
- **** Lotus U.S. Patent # 5,925,348
The actives
- VitalNAD⁺™ (NMN + NADH)
- The combination of NMN and NADH in VitalFactors, designed to support cellular energy. NMN (nicotinamide mononucleotide) is a building block your body uses to make NAD⁺; NADH helps your cells make ATP, the energy they use to function.*
- Resveratrol (ResVida®) + grape skin extract
- A polyphenol antioxidant naturally found in red grapes, from trans-resveratrol (ResVida®) and grape skin extract standardized to resveratrol.
- EGCG (green tea catechin)
- A botanical antioxidant from green tea. Decaffeinated.
- S.O.D. (superoxide dismutase)
- A naturally occurring antioxidant enzyme from Extramel® melon concentrate.
- Vitamins, minerals & amino acids
- L-glutamine, L-arginine, L-lysine and glycine, plus a full B-complex, vitamins A, C, D3, and E, calcium, magnesium, selenium, and potassium. Vitamin and mineral amounts are listed in the Supplement Facts on this page.*
- Enzyme & botanical blend
- Additional enzymes and botanical antioxidants for broader antioxidant support.*
- Other ingredients & allergens
- Citric acid, sodium bicarbonate, potassium bicarbonate, red fruit jelly flavor, berry flavor, steviol glycosides. Contains soy. Sugar free, gluten free, lactose free, yeast free, cholesterol free. No animal ingredients.
Why it’s built this way
VitalFactors has been made and refined by MDR since 1984. The current formula layers VitalNAD+™, the combination of NMN and NADH, into MDR's proprietary complex of amino acids and plant antioxidants (resVida® resveratrol, EGCG, Extramel® S.O.D.) with a full vitamin and mineral panel.
It is built around a weekly rhythm: five days on, two days off. Most customers run it Monday through Friday and skip the weekend. The box of 40 effervescent tablets is sized around exactly that cadence.
The effervescent format is deliberate. The tablets dissolve completely in a glass of water before you drink, so the actives are already in solution.
Selected published research
These studies examine individual ingredients, often at doses and in populations that differ from this product, not the finished formula. They are listed for reference and are not claims about this product.
NMN (nicotinamide mononucleotide)
- The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial (2023). Healthy adults aged 40–65 across several daily dose levels; blood NAD concentrations rose versus placebo.
- Ingestion of β-nicotinamide mononucleotide increased blood NAD levels, maintained walking speed, and improved sleep quality in older adults in a double-blind randomized, placebo-controlled study (2024). Placebo-controlled trial in older adults measuring blood NAD and functional outcomes.
Resveratrol
- Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans (2011). Double-blind crossover of daily trans-resveratrol (resVida) supplementation examining energy metabolism.
- Trans-Resveratrol Supplementation and Endothelial Function during the Fasting and Postprandial Phase: A Randomized Placebo-Controlled Trial in Overweight and Slightly Obese Participants (2017). Four weeks of daily trans-resveratrol; vascular-physiology measurements in adults.
Superoxide dismutase (melon concentrate)
- Dietary Supplementation with a Superoxide Dismutase-Melon Concentrate Reduces Stress, Physical and Mental Fatigue in Healthy People: A Randomised, Double-Blind, Placebo-Controlled Trial (2014). 61 healthy adults, 12 weeks, a daily SOD-melon concentrate versus placebo.
- Effect of an oral supplementation with a proprietary melon juice concentrate (Extramel®) on stress and fatigue in healthy people: a pilot, double-blind, placebo-controlled clinical trial (2009). 70 healthy volunteers aged 30–55, four weeks, on the branded melon concentrate used for S.O.D.
Green tea EGCG
- Green tea catechins prevent low-density lipoprotein oxidation via their accumulation in low-density lipoprotein particles in humans (2016). Human crossover study on catechin absorption and oxidation biomarkers.
- Physiological effects of epigallocatechin-3-gallate (EGCG) on energy expenditure for prospective fat oxidation in humans: A systematic review and meta-analysis (2017). Meta-analysis of human EGCG studies on energy-expenditure physiology.
Ubiquinol (Coenzyme Q10)
- Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men (2018). Randomized crossover in older men comparing the two forms of daily CoQ10 supplementation.
- Comparative Bioavailability of Different Coenzyme Q10 Formulations in Healthy Elderly Individuals (2020). Crossover bioavailability study in 21 healthy adults aged 65–74.
What customers report
Customers rate VitalFactors 4.9 out of 5, with 88% rating it five stars. Reviews are collected from MDR.com customers and filtered for compliance; the same set is shown on the product page.
Quality
- Made by MDR, an American company with 40 years in nutrition science
- Sugar free, gluten free, lactose free, and yeast free
- No artificial colors and no animal ingredients (contains soy)
- Effervescent formula you dissolve in water
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.