Been taking VitalFactors for two months. Love the taste so much that it has become my favorite drink. Hate that I’m supposed to skip 2 days a week but I follow the regimen and am feeling amazing.


Feel As Good as You Did Years Ago
Don’t settle for aging when you can recapture that wonderful feeling of youthful good health with VitalFactors.*
Imagine waking up feeling better than you have in years, with energy, great health, and a new zest for life. That’s exactly how many men and women feel after taking VitalFactors.*
Just two effervescent tablets in a glass of water make a tasty, sparkling berry drink. No caffeine. No sugar.
NAD⁺, Your Body’s Spark for Life
NAD⁺ is found in every cell of your body, where it helps turn the food you eat into energy. Your natural NAD⁺ levels go down as you get older, which is one reason energy and stamina can be harder to keep up.
VitalFactors gives you VitalNAD⁺™, the combination of NMN and NADH designed to support cellular energy, along with resveratrol, EGCG, CoQ10, amino acids, vitamins, and minerals. Together, they help support:
- Energy & Stamina*
- Muscle Tone*
- Immune Defenses*
- Brain Function*
- Heart Health*
- Youthful Skin*
What’s Inside VitalFactors
VitalFactors goes beyond ordinary vitamins. Every glass gives you Youth Factors, Antioxidants, Amino Peptides, BioProtectors, and Enzymes in one proprietary blend.
VitalNAD⁺™NMN and NADH
ResveratrolresVida® resveratrol, grape skin and grape seed extracts
EGCGGreen tea extract
Superoxide DismutaseS.O.D. and catalase from Extramel® melon
Plus lycopene, CoQ10, amino peptides (L-glutamine, arginine, lysine, glycine, and ornithine), lotus seed extract, laminaria seaweed, soy isoflavones, and essential vitamins and minerals. Two tablets in a glass of water release Youth Factors, Antioxidants, Peptides and Enzymes that help your body to repair, renew, and rebuild.*

How to Take VitalFactors
VitalFactors has no caffeine, so you shouldn’t feel jittery or “amped.” For best results, take it at least 30 minutes before eating or 2 hours after a meal, and not right before bed.
- Drop 2 tablets into 8 oz of water.
- Let them fully dissolve. It becomes a light, sparkling drink. Add ice if you want it cold, then enjoy.
- Take it five days on and two days off. Most people take it on their busy weekdays and skip the weekend, but the key is staying consistent.
Each box has 40 tablets, enough for 20 servings, or four weeks.
Backed by MDR, Leaders in Nutrition Science Since 1984
Join the millions of people who have trusted their health to MDR. Start your VitalFactors today.
- 1984
- The year MDR began making nutritional formulas
- 2 million+
- Customers have trusted MDR with their health
- PDR
- Decades ago, MDR made the first patented AM/PM multivitamin, antioxidant formulation listed in the Physician’s Desk Reference

“I have taken VitalFactors and other MDR products religiously for over 30 years! When you think I topped the charts before Elvis, and I am still performing, feeling great at 92, you can see why I call VitalFactors my Fountain of Youth!”

“Fitness and nutrition go hand in hand. That's why I take VitalFactors as my favorite natural energizer.”
What people say.
At age 76, I feel my absolute best when I take Vital Factors. It provides me the energy I need and the mental alertness to accomplish my goals on a daily basis. Also helps me accomplish my exercise goals.
THIS PRODUCT IS WAY BETTER THAN ALL MY EXPECTATIONS. IT IS MY FAVORITE SUPPLIMENT. I AM 71. THANK YOU
Product Overview
VitalFactors is an age-defying nutritional complex of vitamins, minerals, amino acids, antioxidants, and botanical compounds, pressed into effervescent tablets you drop into a glass of water, two per serving, five days on and two days off. It supports steady energy, focus, and healthy aging.*
The format is the difference. A VitalFactors tablet dissolves completely in under two minutes, so the actives are already in solution before you take a sip. No capsule shell, nothing to swallow. Effervescents are how Europeans have taken their micronutrients for decades: in water, as a drink.*
Inside every glass is MDR's proprietary cellular-support blend built around VitalNAD⁺, resveratrol, EGCG, and S.O.D., alongside a full spectrum of vitamins, minerals, amino acids, enzymes, and plant antioxidants, dozens of ingredients working together rather than one isolated nutrient working alone. They're chosen to support the systems your day actually runs on: cellular energy and stamina, antioxidant defense against everyday oxidative stress, vascular and immune wellness, and the foundations of healthy skin, hair, nails, and focus.*
What most people notice first is steady energy, a clean, even lift that carries through the afternoon instead of spiking and crashing. There's no caffeine and no stimulants in VitalFactors, so it works alongside your morning coffee instead of competing with it, and it won't leave you wired at night.*
VitalFactors is built around a weekly rhythm. The formula is designed for a 5-days-on, 2-days-off cycle. Most people run it Monday through Friday and skip the weekend. Your box of 40 effervescent tablets is built around exactly that cadence.
It comes from MDR, Medical Doctors Research, an American company that has been formulating nutrition since 1984. More than forty years of clinical formulation sit behind every tablet, and every ingredient is listed on this page. It's sugar free, gluten free, lactose free, and yeast free, with no artificial colors and no animal ingredients (it does contain soy).
If you want VitalNAD+, resveratrol, EGCG and S.O.D. alongside your usual routine, in a sparkling glass of water on a five-days-on rhythm, VitalFactors is a good fit.*
What’s inside
What Is VitalNAD+™?
VitalNAD+™ is the combination of NMN and NADH in VitalFactors®, designed to support cellular energy.
- Q. What is NAD, and why does my body need it?
- NAD stands for nicotinamide adenine dinucleotide, a natural coenzyme, a helper molecule found in your cells. It exists in two forms, NAD+ and NADH, which your body continually converts from one to the other to help turn food into energy. NAD+ also supports enzymes involved in DNA repair and normal cell function.
- Q. What is NMN?
- NMN stands for nicotinamide mononucleotide. It is a building block your body uses to make NAD+. Human clinical studies have shown that NMN supplementation can increase NAD+ levels in the blood.
- Q. What is NADH?
- NADH is the form of NAD that carries electrons used in energy production. It plays a role in your mitochondria, the energy-producing structures inside your cells, to help make ATP, the energy your cells use to function.
- Q. Why does VitalFactors include both?
- They have complementary roles: NMN helps your body make NAD+, while NADH participates in producing ATP. We include both to support this essential energy system.
- Q. What does cellular energy mean for my everyday life?
- Your body needs energy every moment of every day. The energy processes involving NAD+ and NADH help:
- Power your heart as it pumps blood throughout your body.
- Fuel your brain as it processes information, learns and remembers.
- Keep your muscles working so you can move and stay active.
Supporting cellular energy helps your body perform the essential functions that keep you strong, focused and on the go with youthful vitality and good health.*
Sugar free · gluten free · lactose free · yeast free · cholesterol free · no artificial colors · no animal ingredients.
Allergens: Contains soy.

Supplement Facts
Serving Size: 2 Tablets · Servings Per Container: 20
- Calories24
- Total Carbohydrates0.48 g<1%†
- Sodium274 mg12%
- Vitamin A (as Retinyl Palmitate)30 mcg RAE2%
- Vitamin C (as L-Ascorbic Acid)100 mg111%
- Vitamin D3 (as Cholecalciferol)12.5 mcg (500 IU)63%
- Vitamin E (as D-Alpha-Tocopherol Acetate)10 mg67%
- Vitamin B1 (from Thiamin Hydrochloride)3 mg250%
- Vitamin B2 (as Riboflavin)3.4 mg262%
- Niacinamide24 mg150%
- Vitamin B6 (from Pyridoxine)6 mg353%
- Folic Acid (from Pteroyl-L-Monoglutamic Acid)200 mcg DFE50%
- Vitamin B12 (from Methylcobalamin)200 mcg8333%
- Biotin50 mcg167%
- Pantothenic Acid2 mg40%
- Calcium (from Calcium Carbonate)50 mg4%
- Magnesium (from Trimagnesium Dicitrate)60 mg14%
- Selenium (from Selenomethionine)20 mcg40%
- Potassium330 mg7%
Proprietary Blend3.524 g (3524 mg)
- L-Glutamine*
- NMN (ß-Nicotinamide Mononucleotide)*
- Arginine (as L-Arginine Hydrochloride)*
- Lysine (as L-Lysine Hydrochloride)*
- Glycine*
- Monk Fruit Extract (Momordica Grosvenovi, Fruit)*
- Grape Skin Extract (40% Resveratrol)*
- Coenzyme Q10*
- Grape Seed Extract (Vitis Vinifera)(95% Proanthocyanidins)*
- Soy Isoflavones (contains Soy)*
- Green Tea Extract (EGCG - Epigallocatechin Gallate)*
- Laminaria Japonica Seaweed (80% Polysaccharides)*
- Resveratrol (from resVida®**)*
- Lycopene*
- Superoxide Dismutase/Catalase (from Extramel®*** Melon)*
- Ornithine (as L-Ornithine Hydrochloride)*
- Lotus Seed Extract (Nelumbo Nucifera ****)*
- NADH (Nicotinamide Adenine Dinucleotide Hydrogen)*
- † Percent Daily Values are based on a 2,000 calorie diet
- * Daily Value not established.
- ** Resvida® is a U.S. & international registered trademark of DSM (Netherlands).
- *** Extramel® is a U.S. registered trademark of Bionov Corp.
- **** Lotus U.S. Patent # 5,925,348
Other ingredients: Citric Acid, Sodium Bicarbonate, Potassium Bicarbonate, Red Fruit Jelly Flavor, Berry Flavor, Steviol Glycosides.
Further reading
- What NAD⁺ Actually Is: and Why It Comes Up in Every Conversation About AgingNAD⁺ is in every cell you have, and levels measure lower in older adults. Here is what the research establishes, what it does not, and how to read a label that mentions it.
- Why Cycle a Supplement Five Days On, Two Days Off?Almost every supplement label says "daily". A few are built around a deliberate pause instead. Here is what cycling is for, where the idea comes from, and what an effervescent format changes about it.
- Pure Resveratrol: What "Pure" Should Actually Mean on the LabelMost resveratrol on the shelf comes from Japanese knotweed, not grapes, and "500 mg" usually describes the extract rather than the resveratrol in it. Here is how to read the difference.
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Warnings & usage
- Do not exceed the recommended dose. Always follow the directions on the product label.
- If you are pregnant, nursing, taking medication, or managing a medical condition, consult your healthcare professional before use.
- Keep out of reach of children.
- Store in a cool, dry place away from direct sunlight. Do not use if the safety seal is broken or missing.
- Discontinue use and consult a healthcare professional if any adverse reaction occurs.
